


About

About Dr Karwan Moutasim
Karwan Moutasim is a consultant pathologist at University Hospital Southampton and an honorary associate professor at University of Southampton Faculty of Medicine.

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Qualifications
-
Bachelor of Dental Surgery (BDS)
University of Jordan 2002 -
Membership of the Faculty of Dentistry (MFD RCS)
Royal College of Surgeons in Ireland 2006 -
MSc Experimental Oral Medicine
King's College London 2007 -
Membership in Oral Medicine (MOMed RCS)
Royal College of Surgeons of Edinburgh 2010 -
PhD
University of Southampton 2012 -
FRCPath
Royal College of Pathologists 2016 -
PGCert Med Ed
University of Dundee 2018 -
Fellowship of the Higher Education Academy 2024
Education
1997-2002
Bachelor of Dental Surgery
University of Jordan
2005-2007
MSc Experimental Oral Medicine
King's College London
2009-2012
PhD Cancer Sciences
University of Southampton
Publications

Selected Publications
1. Sreekumar R, Al-Saihaati H, Emaduddin M, Moutasim K, Mellone M, Patel A et al. The ZEB2-dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer. Mol Oncol 2021;15(8)2065-2083.
2. Primrose JN, Pugh SA, Thomas G, Ellis M, Moutasim K, Mant D. Intratumoural immune signature to identify patients with primary colorectal cancer who do not require follow-up after resection: an observational study. Health Technol Assess. 2021;25(21):1-32.
3. Fleming JC, Woo J, Moutasim K, Hanley CJ, Frampton SJ, Wood O et al. CTEN induces tumour cell invasion and survival and is prognostic in radiotherapy-treated head and neck cancer. Cancers (Basel) 2020;12(10):2963.
4. Sreekumar R, Emaduddin M, Al-Saihati, Moutasim K, Chan J, Spampinato M et al. Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC. Cell Death Dis 2019;10(10):703.
5. Packwood K, Martland G, Sommerlad M, Shaw E, Moutasim K, Thomas G et al. Breast cancer in patients with germline TP53 pathogenic variants have typical tumour characteristics - the Cohort study of TP53 carrier early onset breast cancer (COPE study). J Pathol Clin Res 2019; 5(3):189-198.
6. Fleming JC, Woo J, Moutasim K, Mellone M, Frampton SJ, Mead A et al. HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma. Br J Cancer 2019;120(3):356-367.
7. Sreekumar R, Harris S, Moutasim K, DeMateos R, Patel A, Emo K et al. Assessment of nuclear ZEB2 as a biomarker for colorectal cancer outcome and TNM risk stratification. JAMA Netw Open 2018;1(6):e183115.
8. Haynes HR, Killick-Cole CL, Hares KM, Redondo J, Kemp KC, Moutasim K, Faulkner C, Wilkins A, Kurian KM. Evaluation of the quality of RNA extracted from archival FFPE glioblastoma and epilepsy surgical samples for gene expression assays. J Clin Pathol 2018;71(8):695-701.
9. Pugh S, Thiebaut R, Bridgewater J, Grisoni ML, Moutasim K, Rousseau F, Thomas GJ, Griffiths G, Liebaert F, Primrose J, Laurent-Puig P. Association between miR-31-3p expression and cetuximab efficacy in patients with KRAS wild-type metastatic colorectal cancer: a post-hoc analysis of the New EPOC trial. Oncotarget 2017;8(5):93856-93866.
10. Hanley CJ, Mellone M, Ford K, Thirdborough SM, Mellows T, Frampton SJ, Smith DM, Harden E, Szyndralewiez, Bullock M, Noble F, Moutasim K, King EV, Vijayanand P, Mirnezami AH, Underwood TJ, Ottensmeier CH, Thomas GJ. Targeting the myofibroblastic cancer-associated fibroblast phenotype through inhibition of NOX4. J Natl Cancer Inst 2018;110(1). doi: 10.1093/jnci/djx121.
11. Chee SJ, Lopez M, Mellows T, Gankande S, Moutasim K, Harris S, Clarke J, Vijayanand P, Thomas GJ, Ottensmeier CH. Evaluating the effect of immune cells on the outcome of patients with mesothelioma. Br J Cancer 2017;117(9):1341-1348.
12. Tod J, Hanley CJ, Morgan M, Rucka M, Mellows T, Lopez MA, Kiely P, Moutasim K, Frampton S, Fine D, Johnson C, Marshall JF, Scita G, Jenei V, Thomas GJ. Pro-migratory and TGF--activating functions of v6 integrin are differentially regulated via an Eps8-dependent GTPase switch in pancreatic cancer. J Pathol 2017;243(1):37-50.
13. Lawson J, Robinson-Vyas RJ, McQuillan JP, Paterson A, Christie S, Kidza-Griffiths M, McDuffus LA, Moutasim K, Shaw EC, Kiltie AE, Howat WJ, Hanby AM, Thomas GJ, Smittenaar P. Crowdsourcing for translational research: analysis of biomarker expression using cancer microarrays. Br J Cancer 2017;116(2):237-245.
14. Mellone M, Hanley CJ, Thirdborough S, Mellows T, Garcia E, Woo J, Tod J, Frampton S, Jenei V, Moutasim K, Kabir TD, Brennan PA, Venturi G, Ford K, Herranz N, Lim KP, Clarke J, Lambert DW, Prime SS, Underwood TJ, Vijayanand P, Eliceiri KW, Woelk C, King EV, Gil J, Ottensmeier CH, Thomas GJ. Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis. Aging 2017;9(1):114-132.
15. Moutasim K, Mellows T, Mellone M, Lopez MA, Tod J, Kiely PC, Sapienza K, Greco A, Neill GW, Violette S, Weinreb PH, Marshall JF, Ottensmeier CH, Sayan AE, Jenei V, Thomas GJ. Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function. J Pathol 2014;233(2):196-208.
16. McLeod NM, Moutasim K, Brennan PA, Thomas G, Jenei V. In vitro effect of bisphosphonates on oral keratinocytes and fibroblasts. J Oral Maxillofac Surg 2014;72(3):503-9.
17. Nadendla SK, Hazan A, Ward M, Harper LJ, Moutasim K, Bianchi LS, Naase M, Ghali L, Thomas GJ, Prowse DM, Philpott MP, Neill GW. Gli1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state. PLoS One 2011;6(5):e20271.
18. Marsh D, Suchak K, Moutasim K, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N, Violette SM, Weinreb PH, Chester KA, Chana JS, Marshall JF, Hart IR, Hackshaw AK, Piper K, Thomas GJ. Stromal features are predictive of disease mortality in oral cancer patients. J Pathol 2011;223(4):470-81.
19. Moutasim K, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF, Fortune F, Tilakaratne WM, Hart IR, Thomas GJ. Betel-derived alkaloid up-regulates keratinocyte v6 integrin expression and promotes oral submucous fibrosis. J Pathol 2011;223(3):366-77.
20. Underwood TJ, Derouet MF, White MJ, Noble F, Moutasim K, Smith E, Drew PA, Thomas GJ, Primrose JN, Blaydes JP. A comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture. Biol Cell 2010;102(12):635-44.
21. Yap LF, Jenei V, Robinson CM, Moutasim K, Brenn TM, Threadgold SP, Lopes V, Wei W, Thomas GJ, Paterson IC. Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation. Oncogene 2009;28(27):2524-34.
22. El-Maaytah M, [....] Moutasim K, et al. Willingness of Jordanian clinicians to treat a hepatitis B-infected patient. Int J Oral Maxfac Implants 2008;39(4):e-147-51.
23. El-Maaytah M, Al Kayed A, Al Qudah M, Al Ahmad H, Moutasim K, Jerjes W et al. Willingness of dentists in Jordan to treat HIV-infected patients. Oral Dis 2005;11(5):318-22.
Reviews
1. Collins L, Moutasim K. Current concepts in PD-L1 testing in head and neck cancer. Diagn Histopathol 2023 [in press].
2. Moutasim K, Thomas GJ. Genomic alterations in salivary gland carcinomas: an illustrated update. Diagn Histopathol 2022.
DOI: https://doi.org/10.1016/j.mpdhp.2022.02.005
3. Moutasim K, Thomas GJ. Molecular update - salivary gland tumours. Diagn Histopathol 2020;26(4):159-164.
4. Moutasim K, Thomas GJ, Barrett AW. Papillary and verrucous lesions of the oral mucosa. Diagn Histopathol 2017;23(6):243-249.
5. Moutasim K, Robinson CM, Thavaraj S. Human papillomavirus detection in diagnostic head and neck histopathology. Diagn Histopathol 2015;21(2):77-84.
6. Moutasim K, Tappuni AR. Current concepts in the pathogenesis and management of oral mucositis as a complication of cancer therapy. J Dis Oral Health 2008;9:17-23.
7. Poate TW, Sharma R, Moutasim K, Escudier MP, Warnakulasuriya S. Orofacial presentations of sarcoidosis - a case series and review of the literature. Br Dent J 2008;205(8):437-42.
Clinical Case Reports / Series
1. Alsabbagh Y, Higgs N, Moutasim K, Foria V, Webb R. Epstein-Barr virus positive mucocutaneous ulcer presenting as medication-related osteonecrosis of the jaw. Adv in Oral and Maxfac Surg 2021;3:100096.
2. Jenkyn I, Moutasim K, King A, Sharma S. Nodular fasciitis of the temporomandibular joint: a case presentation. J Oral Maxillofac Surg 2018;56:70-73.
3. Moutasim K, Shirlaw PJ, Challacombe SJ. Cowden's syndrome impacting on oral health. J Dis Oral Health 2009;10:131-134.
4. Moutasim K, Shirlaw PJ, Escudier MP, Poate TWJ. Congenital heart block associated with Sjogren syndrome. Int Arch Med 2(1):2.
5. Moutasim K, Poate TW, Setterfield JF, Challacombe SJ. A case of vulvovaginal gingival lichen planus in association with Good's syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105(3):e57-60.
Book Contributions
1. Moutasim K, Nystrom ML, Thomas GJ. Cell migration and invasion assays. In Methods Mol Biol 2011;731:333-43.
2. Moutasim K, Thomas GJ. Soft tissue tumours of the oral and maxillofacial region. In Oral medicine and pathology - a guide to diagnosis and treatment (2010).